TNS3-HUS1 Fusion FISH Probe
The TNS3-HUS1 Fusion FISH Probe is used to confirm a fusion of the TNS3 and HUS1 genes. The fusion of the TNS3 and HUS1 genes has been associated with Sarcoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNS3-HUS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-RERE | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-REOR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-REGO | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-REGR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-REAQ | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-ORRE | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-OROR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-ORGO | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GORE | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GOOR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GOGO | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GOGR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GRRE | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GROR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GRGO | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GRGR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-AQRE | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-AQOR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-AQGO | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-AQGR | 20 (40 μL) | 200 μL |
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| TNS3-HUS1-20-AQAQ | 20 (40 μL) | 200 μL |
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HUS1 Gene Summary
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Gene Name: HUS1 Checkpoint Clamp Component
Chromosome: CHR7: 48002884 -48019222
Locus: 7p12.3
TNS3 Gene Summary
The Tensin 3 (TNS3) gene is located on chr7 :47314751-47621742 at 7p12.3.
Gene Name: Tensin 3
Chromosome: CHR7: 47314751 -47621742
Locus: 7p12.3
Gene Diseases
The TNS3 HUS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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