TNS1-SPTBN1 Fusion FISH Probe
The TNS1-SPTBN1 Fusion FISH Probe is used to confirm a fusion of the TNS1 and SPTBN1 genes. The fusion of the TNS1 and SPTBN1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNS1-SPTBN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-RERE | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-REOR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-REGO | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-REGR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-REAQ | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-ORRE | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-OROR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-ORGO | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GORE | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GOOR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GOGO | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GOGR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GRRE | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GROR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GRGO | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GRGR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-AQRE | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-AQOR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-AQGO | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-AQGR | 20 (40 μL) | 200 μL |
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| TNS1-SPTBN1-20-AQAQ | 20 (40 μL) | 200 μL |
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SPTBN1 Gene Summary
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Spectrin Beta, Non-erythrocytic 1
Chromosome: CHR2: 54683453 -54898583
Locus: 2p16.2
TNS1 Gene Summary
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Gene Name: Tensin 1
Chromosome: CHR2: 218664511 -218808796
Locus: 2q35
Gene Diseases
The TNS1 SPTBN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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