TNPO1-MEF2C Fusion FISH Probe
The TNPO1-MEF2C Fusion FISH Probe is used to confirm a fusion of the TNPO1 and MEF2C genes. The fusion of the TNPO1 and MEF2C genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNPO1-MEF2C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TNPO1-MEF2C-20-AQAQ | 20 (40 μL) | 200 μL |
|
TNPO1 Gene Summary
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
Gene Name: Transportin 1
Chromosome: CHR5: 72112417 -72210215
Locus: 5q13.2
MEF2C Gene Summary
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Gene Name: Myocyte Enhancer Factor 2C
Chromosome: CHR5: 88014057 -88199922
Locus: 5q14.3
Gene Diseases
The TNPO1 MEF2C Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|