TNIK-STXBP5L Fusion FISH Probe
The TNIK-STXBP5L Fusion FISH Probe is used to confirm a fusion of the TNIK and STXBP5L genes. The fusion of the TNIK and STXBP5L genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNIK-STXBP5L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-RERE | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-REOR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-REGO | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-REGR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-REAQ | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-ORRE | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-OROR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-ORGO | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GORE | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GOOR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GOGO | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GOGR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GRRE | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GROR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GRGO | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GRGR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-AQRE | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-AQOR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-AQGO | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-AQGR | 20 (40 μL) | 200 μL |
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| TNIK-STXBP5L-20-AQAQ | 20 (40 μL) | 200 μL |
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STXBP5L Gene Summary
The protein encoded by this gene is similar to syntaxin-binding protein 5 and contains ten N-terminal WD40 repeats, four variable region WD40 repeats, and a C-terminal R-SNARE domain. Studies of the orthologous proteins in mouse and rat have shown that the encoded protein may inhibit exocytosis in neurosecretory cells, and may negatively regulate the secretion of insulin. A missense variant in this gene is likely the cause of an infantile-onset neurodegenerative disorder diagnosed in two siblings of consanguineous parents. [provided by RefSeq, Jan 2017]
Gene Name: Syntaxin Binding Protein 5 Like
Chromosome: CHR3: 120627049 -121143608
Locus: 3q13.33
TNIK Gene Summary
Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Gene Name: TRAF2 And NCK Interacting Kinase
Chromosome: CHR3: 170780291 -171178197
Locus: 3q26.2-q26.31
Gene Diseases
The TNIK STXBP5L Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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