TNIK-KCNMB2 Fusion FISH Probe
The TNIK-KCNMB2 Fusion FISH Probe is used to confirm a fusion of the TNIK and KCNMB2 genes. The fusion of the TNIK and KCNMB2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNIK-KCNMB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-RERE | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-REOR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-REGO | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-REGR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-REAQ | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-ORRE | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-OROR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-ORGO | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GORE | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GOOR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GOGO | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GOGR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GRRE | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GROR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GRGO | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GRGR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-AQRE | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-AQOR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-AQGO | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-AQGR | 20 (40 μL) | 200 μL |
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| TNIK-KCNMB2-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNMB2 Gene Summary
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
Gene Name: Potassium Calcium-activated Channel Subfamily M Regulatory Beta Subunit 2
Chromosome: CHR3: 178254223 -178562217
Locus: 3q26.32
TNIK Gene Summary
Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Gene Name: TRAF2 And NCK Interacting Kinase
Chromosome: CHR3: 170780291 -171178197
Locus: 3q26.2-q26.31
Gene Diseases
The TNIK KCNMB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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