TNFRSF1A-SCNN1A Fusion FISH Probe
The TNFRSF1A-SCNN1A Fusion FISH Probe is used to confirm a fusion of the TNFRSF1A and SCNN1A genes. The fusion of the TNFRSF1A and SCNN1A genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNFRSF1A-SCNN1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-RERE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-REOR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-REGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-REGR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-REAQ | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-ORRE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-OROR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-ORGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GORE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GOOR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GOGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GOGR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GRRE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GROR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GRGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GRGR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-AQRE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-AQOR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-AQGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-AQGR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-SCNN1A-20-AQAQ | 20 (40 μL) | 200 μL |
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SCNN1A Gene Summary
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]
Gene Name: Sodium Channel Epithelial 1 Alpha Subunit
Chromosome: CHR12: 6456008 -6486523
Locus: 12p13.31
TNFRSF1A Gene Summary
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
Gene Name: TNF Receptor Superfamily Member 1A
Chromosome: CHR12: 6437922 -6451283
Locus: 12p13.31
Gene Diseases
The TNFRSF1A SCNN1A Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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