TNFRSF1A-CHD4 Fusion FISH Probe
The TNFRSF1A-CHD4 Fusion FISH Probe is used to confirm a fusion of the TNFRSF1A and CHD4 genes. The fusion of the TNFRSF1A and CHD4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNFRSF1A-CHD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-RERE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-REOR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-REGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-REGR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-REAQ | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-ORRE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-OROR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-ORGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GORE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GOOR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GOGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GOGR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GRRE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GROR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GRGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GRGR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-AQRE | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-AQOR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-AQGO | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-AQGR | 20 (40 μL) | 200 μL |
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| TNFRSF1A-CHD4-20-AQAQ | 20 (40 μL) | 200 μL |
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CHD4 Gene Summary
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Name: Chromodomain Helicase DNA Binding Protein 4
Chromosome: CHR12: 6679247 -6716551
Locus: 12p13.31
TNFRSF1A Gene Summary
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
Gene Name: TNF Receptor Superfamily Member 1A
Chromosome: CHR12: 6437922 -6451283
Locus: 12p13.31
Gene Diseases
The TNFRSF1A CHD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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