TNFRSF10B-LOXL2 Fusion FISH Probe
The TNFRSF10B-LOXL2 Fusion FISH Probe is used to confirm a fusion of the TNFRSF10B and LOXL2 genes. The fusion of the TNFRSF10B and LOXL2 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TNFRSF10B-LOXL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-RERE | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-REOR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-REGO | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-REGR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-REAQ | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-ORRE | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-OROR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-ORGO | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GORE | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GOOR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GOGO | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GOGR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GRRE | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GROR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GRGO | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GRGR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-AQRE | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-AQOR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-AQGO | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-AQGR | 20 (40 μL) | 200 μL |
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| TNFRSF10B-LOXL2-20-AQAQ | 20 (40 μL) | 200 μL |
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LOXL2 Gene Summary
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Gene Name: Lysyl Oxidase Like 2
Chromosome: CHR8: 23154409 -23261722
Locus: 8p21.3
TNFRSF10B Gene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: TNF Receptor Superfamily Member 10b
Chromosome: CHR8: 22877647 -22926700
Locus: 8p21.3
Gene Diseases
The TNFRSF10B LOXL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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