TMX3-METTL4 Fusion FISH Probe
The TMX3-METTL4 Fusion FISH Probe is used to confirm a fusion of the TMX3 and METTL4 genes. The fusion of the TMX3 and METTL4 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMX3-METTL4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-RERE | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-REOR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-REGO | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-REGR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-REAQ | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-ORRE | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-OROR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-ORGO | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GORE | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GOOR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GOGO | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GOGR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GRRE | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GROR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GRGO | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GRGR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-AQRE | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-AQOR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-AQGO | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-AQGR | 20 (40 μL) | 200 μL |
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| TMX3-METTL4-20-AQAQ | 20 (40 μL) | 200 μL |
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TMX3 Gene Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
Gene Name: Thioredoxin Related Transmembrane Protein 3
Chromosome: CHR18: 66340924 -66382353
Locus: 18q22.1
METTL4 Gene Summary
The Methyltransferase Like 4 (METTL4) gene is located on chr18 :2537523-2571489 at 18p11.32.
Gene Name: Methyltransferase Like 4
Chromosome: CHR18: 2537523 -2571489
Locus: 18p11.32
Gene Diseases
The TMX3 METTL4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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