TMX2-MED19 Fusion FISH Probe
The TMX2-MED19 Fusion FISH Probe is used to confirm a fusion of the TMX2 and MED19 genes. The fusion of the TMX2 and MED19 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMX2-MED19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-RERE | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-REOR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-REGO | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-REGR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-REAQ | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-ORRE | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-OROR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-ORGO | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GORE | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GOOR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GOGO | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GOGR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GRRE | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GROR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GRGO | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GRGR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-AQRE | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-AQOR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-AQGO | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-AQGR | 20 (40 μL) | 200 μL |
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| TMX2-MED19-20-AQAQ | 20 (40 μL) | 200 μL |
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TMX2 Gene Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017]
Gene Name: Thioredoxin Related Transmembrane Protein 2
Chromosome: CHR11: 57479994 -57508445
Locus: 11q12.1
MED19 Gene Summary
The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: Mediator Complex Subunit 19
Chromosome: CHR11: 57471186 -57479673
Locus: 11q12.1
Gene Diseases
The TMX2 MED19 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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