TMTC2-LYZ Fusion FISH Probe
The TMTC2-LYZ Fusion FISH Probe is used to confirm a fusion of the TMTC2 and LYZ genes. The fusion of the TMTC2 and LYZ genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMTC2-LYZ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-RERE | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-REOR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-REGO | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-REGR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-REAQ | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-ORRE | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-OROR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-ORGO | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GORE | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GOOR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GOGO | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GOGR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GRRE | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GROR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GRGO | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GRGR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-AQRE | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-AQOR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-AQGO | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-AQGR | 20 (40 μL) | 200 μL |
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| TMTC2-LYZ-20-AQAQ | 20 (40 μL) | 200 μL |
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LYZ Gene Summary
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
Gene Name: Lysozyme
Chromosome: CHR12: 69742133 -69748013
Locus: 12q15
TMTC2 Gene Summary
The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Transmembrane And Tetratricopeptide Repeat Containing 2
Chromosome: CHR12: 83080933 -83528067
Locus: 12q21.31
Gene Diseases
The TMTC2 LYZ Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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