TMPRSS2-TMEFF2 Fusion FISH Probe
The TMPRSS2-TMEFF2 Fusion FISH Probe is used to confirm a fusion of the TMPRSS2 and TMEFF2 genes. The fusion of the TMPRSS2 and TMEFF2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMPRSS2-TMEFF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-RERE | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-REOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-REGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-REGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-REAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-ORRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-OROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-ORGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GORE | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GOOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GOGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GOGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GRRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GRGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GRGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-AQRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-AQOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-AQGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-AQGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-TMEFF2-20-AQAQ | 20 (40 μL) | 200 μL |
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TMPRSS2 Gene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: Transmembrane Protease, Serine 2
Chromosome: CHR21: 42836477 -42880085
Locus: 21q22.3
TMEFF2 Gene Summary
This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Name: Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2
Chromosome: CHR2: 192814746 -193059644
Locus: 2q32.3
Gene Diseases
The TMPRSS2 TMEFF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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