TMPRSS2-MRPS6 Fusion FISH Probe
The TMPRSS2-MRPS6 Fusion FISH Probe is used to confirm a fusion of the TMPRSS2 and MRPS6 genes. The fusion of the TMPRSS2 and MRPS6 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TMPRSS2-MRPS6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TMPRSS2-MRPS6-20-AQAQ | 20 (40 μL) | 200 μL |
|
TMPRSS2 Gene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: Transmembrane Protease, Serine 2
Chromosome: CHR21: 42836477 -42880085
Locus: 21q22.3
MRPS6 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S6
Chromosome: CHR21: 35445822 -35515334
Locus: 21q22.11
Gene Diseases
The TMPRSS2 MRPS6 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|