TMPRSS2-INPP4B Fusion FISH Probe
The TMPRSS2-INPP4B Fusion FISH Probe is used to confirm a fusion of the TMPRSS2 and INPP4B genes. The fusion of the TMPRSS2 and INPP4B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMPRSS2-INPP4B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-RERE | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-REOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-REGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-REGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-REAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-ORRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-OROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-ORGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GORE | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GOOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GOGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GOGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GRRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GRGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GRGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-AQRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-AQOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-AQGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-AQGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-INPP4B-20-AQAQ | 20 (40 μL) | 200 μL |
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TMPRSS2 Gene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: Transmembrane Protease, Serine 2
Chromosome: CHR21: 42836477 -42880085
Locus: 21q22.3
INPP4B Gene Summary
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Gene Name: Inositol Polyphosphate-4-phosphatase Type II B
Chromosome: CHR4: 142949181 -143767604
Locus: 4q31.21
Gene Diseases
The TMPRSS2 INPP4B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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