TMPRSS2-BRAF Fusion FISH Probe
The TMPRSS2-BRAF Fusion FISH Probe is used to confirm a fusion of the TMPRSS2 and BRAF genes. The fusion of the TMPRSS2 and BRAF genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMPRSS2-BRAF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-RERE | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-REOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-REGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-REGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-REAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-ORRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-OROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-ORGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GORE | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GOOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GOGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GOGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GRRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GROR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GRGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GRGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-AQRE | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-AQOR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-AQGO | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-AQGR | 20 (40 μL) | 200 μL |
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| TMPRSS2-BRAF-20-AQAQ | 20 (40 μL) | 200 μL |
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BRAF Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812 -140624564
Locus: 7q34
TMPRSS2 Gene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: Transmembrane Protease, Serine 2
Chromosome: CHR21: 42836477 -42880085
Locus: 21q22.3
Gene Diseases
The TMPRSS2 BRAF Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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