TMPRSS11D-SPINK2 Fusion FISH Probe
The TMPRSS11D-SPINK2 Fusion FISH Probe is used to confirm a fusion of the TMPRSS11D and SPINK2 genes. The fusion of the TMPRSS11D and SPINK2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMPRSS11D-SPINK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-RERE | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-REOR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-REGO | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-REGR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-REAQ | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-ORRE | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-OROR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-ORGO | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GORE | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GOOR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GOGO | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GOGR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GRRE | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GROR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GRGO | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GRGR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-AQRE | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-AQOR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-AQGO | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-AQGR | 20 (40 μL) | 200 μL |
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| TMPRSS11D-SPINK2-20-AQAQ | 20 (40 μL) | 200 μL |
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SPINK2 Gene Summary
This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Name: Serine Peptidase Inhibitor, Kazal Type 2
Chromosome: CHR4: 57676033 -57687893
Locus: 4q12
TMPRSS11D Gene Summary
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Protease, Serine 11D
Chromosome: CHR4: 68686593 -68749716
Locus: 4q13.2
Gene Diseases
The TMPRSS11D SPINK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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