TMEM91-TGFB1 Fusion FISH Probe
The TMEM91-TGFB1 Fusion FISH Probe is used to confirm a fusion of the TMEM91 and TGFB1 genes. The fusion of the TMEM91 and TGFB1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMEM91-TGFB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-RERE | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-REOR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-REGO | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-REGR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-REAQ | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-ORRE | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-OROR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-ORGO | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GORE | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GOOR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GOGO | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GOGR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GRRE | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GROR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GRGO | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GRGR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-AQRE | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-AQOR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-AQGO | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-AQGR | 20 (40 μL) | 200 μL |
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| TMEM91-TGFB1-20-AQAQ | 20 (40 μL) | 200 μL |
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TGFB1 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Gene Name: Transforming Growth Factor Beta 1
Chromosome: CHR19: 41836811 -41859831
Locus: 19q13.2
TMEM91 Gene Summary
The Transmembrane Protein 91 (TMEM91) gene is located on chr19 :41869870-41889987 at 19q13.2.
Gene Name: Transmembrane Protein 91
Chromosome: CHR19: 41869870 -41889987
Locus: 19q13.2
Gene Diseases
The TMEM91 TGFB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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