TMEM87B-MERTK Fusion FISH Probe
The TMEM87B-MERTK Fusion FISH Probe is used to confirm a fusion of the TMEM87B and MERTK genes. The fusion of the TMEM87B and MERTK genes has been associated with Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Breast Invasive Carcinoma, Adrenocortical Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMEM87B-MERTK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-RERE | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-REOR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-REGO | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-REGR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-REAQ | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-ORRE | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-OROR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-ORGO | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GORE | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GOOR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GOGO | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GOGR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GRRE | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GROR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GRGO | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GRGR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-AQRE | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-AQOR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-AQGO | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-AQGR | 20 (40 μL) | 200 μL |
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| TMEM87B-MERTK-20-AQAQ | 20 (40 μL) | 200 μL |
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MERTK Gene Summary
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
Gene Name: MER Proto-oncogene, Tyrosine Kinase
Chromosome: CHR2: 112656190 -112786945
Locus: 2q13
TMEM87B Gene Summary
This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016]
Gene Name: Transmembrane Protein 87B
Chromosome: CHR2: 112812799 -112876895
Locus: 2q13
Gene Diseases
The TMEM87B MERTK Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
| Adrenocortical Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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