TMEM59-ARFGEF2 Fusion FISH Probe
The TMEM59-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the TMEM59 and ARFGEF2 genes. The fusion of the TMEM59 and ARFGEF2 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMEM59-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| TMEM59-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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TMEM59 Gene Summary
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Name: Transmembrane Protein 59
Chromosome: CHR1: 54497348 -54519111
Locus: 1p32.3
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The TMEM59 ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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