TMEM135-CHEK1 Fusion FISH Probe
The TMEM135-CHEK1 Fusion FISH Probe is used to confirm a fusion of the TMEM135 and CHEK1 genes. The fusion of the TMEM135 and CHEK1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMEM135-CHEK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-RERE | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-REOR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-REGO | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-REGR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-REAQ | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-ORRE | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-OROR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-ORGO | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GORE | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GOOR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GOGO | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GOGR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GRRE | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GROR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GRGO | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GRGR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-AQRE | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-AQOR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-AQGO | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-AQGR | 20 (40 μL) | 200 μL |
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| TMEM135-CHEK1-20-AQAQ | 20 (40 μL) | 200 μL |
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CHEK1 Gene Summary
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Checkpoint Kinase 1
Chromosome: CHR11: 125495035 -125546150
Locus: 11q24.2
TMEM135 Gene Summary
The Transmembrane Protein 135 (TMEM135) gene is located on chr11 :86748885-87039876 at 11q14.2.
Gene Name: Transmembrane Protein 135
Chromosome: CHR11: 86748885 -87039876
Locus: 11q14.2
Gene Diseases
The TMEM135 CHEK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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