TMEM123-MMP7 Fusion FISH Probe
The TMEM123-MMP7 Fusion FISH Probe is used to confirm a fusion of the TMEM123 and MMP7 genes. The fusion of the TMEM123 and MMP7 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMEM123-MMP7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-RERE | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-REOR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-REGO | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-REGR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-REAQ | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-ORRE | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-OROR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-ORGO | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GORE | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GOOR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GOGO | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GOGR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GRRE | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GROR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GRGO | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GRGR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-AQRE | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-AQOR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-AQGO | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-AQGR | 20 (40 μL) | 200 μL |
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| TMEM123-MMP7-20-AQAQ | 20 (40 μL) | 200 μL |
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MMP7 Gene Summary
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
Gene Name: Matrix Metallopeptidase 7
Chromosome: CHR11: 102391238 -102401478
Locus: 11q22.2
TMEM123 Gene Summary
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Protein 123
Chromosome: CHR11: 102267055 -102323775
Locus: 11q22.2
Gene Diseases
The TMEM123 MMP7 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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