TMEM123-MMP20 Fusion FISH Probe
The TMEM123-MMP20 Fusion FISH Probe is used to confirm a fusion of the TMEM123 and MMP20 genes. The fusion of the TMEM123 and MMP20 genes has been associated with Lung Adenocarcinoma, Colon Adenocarcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TMEM123-MMP20-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TMEM123-MMP20-20-AQAQ | 20 (40 μL) | 200 μL |
|
MMP20 Gene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]
Gene Name: Matrix Metallopeptidase 20
Chromosome: CHR11: 102447565 -102496063
Locus: 11q22.2
TMEM123 Gene Summary
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Protein 123
Chromosome: CHR11: 102267055 -102323775
Locus: 11q22.2
Gene Diseases
The TMEM123 MMP20 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
| Colon Adenocarcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|