TMCO7-CDH1 Fusion FISH Probe
The TMCO7-CDH1 Fusion FISH Probe is used to confirm a fusion of the TMCO7 and CDH1 genes. The fusion of the TMCO7 and CDH1 genes has been associated with Breast Invasive Carcinoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMCO7-CDH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-RERE | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-REOR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-REGO | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-REGR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-REAQ | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-ORRE | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-OROR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-ORGO | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GORE | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GOOR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GOGO | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GOGR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GRRE | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GROR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GRGO | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GRGR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-AQRE | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-AQOR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-AQGO | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-AQGR | 20 (40 μL) | 200 μL |
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| TMCO7-CDH1-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH1 Gene Summary
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 1
Chromosome: CHR16: 68771194 -68869444
Locus: 16q22.1
Gene Diseases
The TMCO7 CDH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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