TMC6-TK1 Fusion FISH Probe
The TMC6-TK1 Fusion FISH Probe is used to confirm a fusion of the TMC6 and TK1 genes. The fusion of the TMC6 and TK1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMC6-TK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-RERE | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-REOR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-REGO | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-REGR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-REAQ | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-ORRE | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-OROR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-ORGO | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GORE | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GOOR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GOGO | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GOGR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GRRE | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GROR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GRGO | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GRGR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-AQRE | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-AQOR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-AQGO | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-AQGR | 20 (40 μL) | 200 μL |
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| TMC6-TK1-20-AQAQ | 20 (40 μL) | 200 μL |
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TK1 Gene Summary
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
Gene Name: Thymidine Kinase 1
Chromosome: CHR17: 76170159 -76183285
Locus: 17q25.3
TMC6 Gene Summary
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Channel Like 6
Chromosome: CHR17: 76108998 -76128488
Locus: 17q25.3
Gene Diseases
The TMC6 TK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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