TIMP2-CEP57 Fusion FISH Probe
The TIMP2-CEP57 Fusion FISH Probe is used to confirm a fusion of the TIMP2 and CEP57 genes. The fusion of the TIMP2 and CEP57 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TIMP2-CEP57-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TIMP2-CEP57-20-AQAQ | 20 (40 μL) | 200 μL |
|
TIMP2 Gene Summary
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Gene Name: TIMP Metallopeptidase Inhibitor 2
Chromosome: CHR17: 76849058 -76921472
Locus: 17q25.3
CEP57 Gene Summary
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Centrosomal Protein 57
Chromosome: CHR11: 95523624 -95565857
Locus: 11q21
Gene Diseases
The TIMP2 CEP57 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|