TICAM1-PTPRS Fusion FISH Probe
The TICAM1-PTPRS Fusion FISH Probe is used to confirm a fusion of the TICAM1 and PTPRS genes. The fusion of the TICAM1 and PTPRS genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TICAM1-PTPRS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-RERE | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-REOR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-REGO | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-REGR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-REAQ | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-ORRE | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-OROR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-ORGO | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-ORAQ | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GORE | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GOOR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GOGO | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GOGR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GOAQ | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GRRE | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GROR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GRGO | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GRGR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-GRAQ | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-AQRE | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-AQOR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-AQGO | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-AQGR | 20 (40 μL) | 200 μL |
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| TICAM1-PTPRS-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRS Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type S
Chromosome: CHR19: 5205518 -5340814
Locus: 19p13.3
TICAM1 Gene Summary
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
Gene Name: Toll Like Receptor Adaptor Molecule 1
Chromosome: CHR19: 4815937 -4831737
Locus: 19p13.3
Gene Diseases
The TICAM1 PTPRS Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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