TIAM1-PCBP3 Fusion FISH Probe
The TIAM1-PCBP3 Fusion FISH Probe is used to confirm a fusion of the TIAM1 and PCBP3 genes. The fusion of the TIAM1 and PCBP3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TIAM1-PCBP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-RERE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-REOR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-REGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-REGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-REAQ | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-ORRE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-OROR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-ORGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GORE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GOOR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GOGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GOGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GRRE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GROR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GRGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GRGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQRE | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQOR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQGO | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQGR | 20 (40 μL) | 200 μL |
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| TIAM1-PCBP3-20-AQAQ | 20 (40 μL) | 200 μL |
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TIAM1 Gene Summary
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Gene Name: T-cell Lymphoma Invasion And Metastasis 1
Chromosome: CHR21: 32490735 -32931290
Locus: 21q22.11
PCBP3 Gene Summary
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Poly(rC) Binding Protein 3
Chromosome: CHR21: 47269874 -47362368
Locus: 21q22.3
Gene Diseases
The TIAM1 PCBP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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