TIAM1-FBLIM1 Fusion FISH Probe
The TIAM1-FBLIM1 Fusion FISH Probe is used to confirm a fusion of the TIAM1 and FBLIM1 genes. The fusion of the TIAM1 and FBLIM1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TIAM1-FBLIM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-RERE | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-REOR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-REGO | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-REGR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-REAQ | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-ORRE | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-OROR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-ORGO | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GORE | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GOOR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GOGO | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GOGR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GRRE | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GROR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GRGO | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GRGR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-AQRE | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-AQOR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-AQGO | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-AQGR | 20 (40 μL) | 200 μL |
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| TIAM1-FBLIM1-20-AQAQ | 20 (40 μL) | 200 μL |
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TIAM1 Gene Summary
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Gene Name: T-cell Lymphoma Invasion And Metastasis 1
Chromosome: CHR21: 32490735 -32931290
Locus: 21q22.11
FBLIM1 Gene Summary
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Filamin Binding LIM Protein 1
Chromosome: CHR1: 16085254 -16113084
Locus: 1p36.21
Gene Diseases
The TIAM1 FBLIM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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