TIA1-MRPL33 Fusion FISH Probe
The TIA1-MRPL33 Fusion FISH Probe is used to confirm a fusion of the TIA1 and MRPL33 genes. The fusion of the TIA1 and MRPL33 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TIA1-MRPL33-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-RERE | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-REOR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-REGO | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-REGR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-REAQ | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-ORRE | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-OROR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-ORGO | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-ORAQ | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GORE | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GOOR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GOGO | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GOGR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GOAQ | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GRRE | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GROR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GRGO | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GRGR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-GRAQ | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-AQRE | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-AQOR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-AQGO | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-AQGR | 20 (40 μL) | 200 μL |
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| TIA1-MRPL33-20-AQAQ | 20 (40 μL) | 200 μL |
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TIA1 Gene Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Gene Name: TIA1 Cytotoxic Granule Associated RNA Binding Protein
Chromosome: CHR2: 70436575 -70475779
Locus: 2p13.3
MRPL33 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L33
Chromosome: CHR2: 27994583 -28002608
Locus: 2p23.2
Gene Diseases
The TIA1 MRPL33 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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