TIA1-FAM136A Fusion FISH Probe
The TIA1-FAM136A Fusion FISH Probe is used to confirm a fusion of the TIA1 and FAM136A genes. The fusion of the TIA1 and FAM136A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TIA1-FAM136A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-RERE | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-REOR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-REGO | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-REGR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-REAQ | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-ORRE | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-OROR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-ORGO | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-ORAQ | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GORE | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GOOR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GOGO | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GOGR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GOAQ | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GRRE | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GROR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GRGO | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GRGR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-GRAQ | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-AQRE | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-AQOR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-AQGO | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-AQGR | 20 (40 μL) | 200 μL |
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| TIA1-FAM136A-20-AQAQ | 20 (40 μL) | 200 μL |
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TIA1 Gene Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Gene Name: TIA1 Cytotoxic Granule Associated RNA Binding Protein
Chromosome: CHR2: 70436575 -70475779
Locus: 2p13.3
FAM136A Gene Summary
This gene encodes a mitochondrially localized protein that is highly conserved across species. The gene is expressed in a variety of tissues including human lymphoblast cells and rat neurosensorial epithelium of the cristaampullaris. A mutation in this gene has been associated with familial Meniere's disease, a chronic disorder of the inner ear. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: Family With Sequence Similarity 136 Member A
Chromosome: CHR2: 70523107 -70529220
Locus: 2p13.3
Gene Diseases
The TIA1 FAM136A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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