TIA1-BCL11A Fusion FISH Probe
The TIA1-BCL11A Fusion FISH Probe is used to confirm a fusion of the TIA1 and BCL11A genes. The fusion of the TIA1 and BCL11A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TIA1-BCL11A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-RERE | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-REOR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-REGO | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-REGR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-REAQ | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-ORRE | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-OROR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-ORGO | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-ORAQ | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GORE | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GOOR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GOGO | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GOGR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GOAQ | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GRRE | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GROR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GRGO | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GRGR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-GRAQ | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-AQRE | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-AQOR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-AQGO | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-AQGR | 20 (40 μL) | 200 μL |
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| TIA1-BCL11A-20-AQAQ | 20 (40 μL) | 200 μL |
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TIA1 Gene Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Gene Name: TIA1 Cytotoxic Granule Associated RNA Binding Protein
Chromosome: CHR2: 70436575 -70475779
Locus: 2p13.3
BCL11A Gene Summary
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: B-cell CLL/lymphoma 11A
Chromosome: CHR2: 60678301 -60780633
Locus: 2p16.1
Gene Diseases
The TIA1 BCL11A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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