TIA1-ACTR2 Fusion FISH Probe
The TIA1-ACTR2 Fusion FISH Probe is used to confirm a fusion of the TIA1 and ACTR2 genes. The fusion of the TIA1 and ACTR2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TIA1-ACTR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-RERE | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-REOR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-REGO | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-REGR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-REAQ | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-ORRE | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-OROR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-ORGO | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GORE | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GOOR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GOGO | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GOGR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GRRE | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GROR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GRGO | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GRGR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-AQRE | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-AQOR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-AQGO | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-AQGR | 20 (40 μL) | 200 μL |
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| TIA1-ACTR2-20-AQAQ | 20 (40 μL) | 200 μL |
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TIA1 Gene Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Gene Name: TIA1 Cytotoxic Granule Associated RNA Binding Protein
Chromosome: CHR2: 70436575 -70475779
Locus: 2p13.3
ACTR2 Gene Summary
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ARP2 Actin Related Protein 2 Homolog
Chromosome: CHR2: 65454828 -65498390
Locus: 2p14
Gene Diseases
The TIA1 ACTR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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