THRA-PSMD3 Fusion FISH Probe
The THRA-PSMD3 Fusion FISH Probe is used to confirm a fusion of the THRA and PSMD3 genes. The fusion of the THRA and PSMD3 genes has been associated with Lung Squamous Cell Carcinoma, and Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| THRA-PSMD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-RERE | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-REOR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-REGO | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-REGR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-REAQ | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-ORRE | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-OROR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-ORGO | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GORE | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GOOR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GOGO | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GOGR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GRRE | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GROR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GRGO | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GRGR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-AQRE | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-AQOR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-AQGO | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-AQGR | 20 (40 μL) | 200 μL |
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| THRA-PSMD3-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMD3 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]
Gene Name: Proteasome 26S Subunit, Non-ATPase 3
Chromosome: CHR17: 38137059 -38154212
Locus: 17q21.1
THRA Gene Summary
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Thyroid Hormone Receptor, Alpha
Chromosome: CHR17: 38218445 -38250120
Locus: 17q21.1
Gene Diseases
The THRA PSMD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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