THOP1-NOTCH3 Fusion FISH Probe
The THOP1-NOTCH3 Fusion FISH Probe is used to confirm a fusion of the THOP1 and NOTCH3 genes. The fusion of the THOP1 and NOTCH3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| THOP1-NOTCH3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-RERE | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-REOR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-REGO | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-REGR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-REAQ | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-ORRE | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-OROR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-ORGO | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-ORAQ | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GORE | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GOOR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GOGO | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GOGR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GOAQ | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GRRE | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GROR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GRGO | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GRGR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-GRAQ | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-AQRE | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-AQOR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-AQGO | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-AQGR | 20 (40 μL) | 200 μL |
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| THOP1-NOTCH3-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH3 Gene Summary
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Gene Name: Notch 3
Chromosome: CHR19: 15270443 -15311792
Locus: 19p13.12
THOP1 Gene Summary
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Gene Name: Thimet Oligopeptidase 1
Chromosome: CHR19: 2785505 -2813599
Locus: 19p13.3
Gene Diseases
The THOP1 NOTCH3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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