THAP3-LCK Fusion FISH Probe
The THAP3-LCK Fusion FISH Probe is used to confirm a fusion of the THAP3 and LCK genes. The fusion of the THAP3 and LCK genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| THAP3-LCK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-RERE | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-REOR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-REGO | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-REGR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-REAQ | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-ORRE | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-OROR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-ORGO | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-ORAQ | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GORE | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GOOR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GOGO | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GOGR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GOAQ | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GRRE | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GROR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GRGO | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GRGR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-GRAQ | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-AQRE | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-AQOR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-AQGO | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-AQGR | 20 (40 μL) | 200 μL |
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| THAP3-LCK-20-AQAQ | 20 (40 μL) | 200 μL |
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LCK Gene Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]
Gene Name: LCK Proto-oncogene, Src Family Tyrosine Kinase
Chromosome: CHR1: 32716839 -32751766
Locus: 1p35.2
THAP3 Gene Summary
The THAP Domain Containing 3 (THAP3) gene is located on chr1 :6685209-6695646 at 1p36.31.
Gene Name: THAP Domain Containing 3
Chromosome: CHR1: 6685209 -6695646
Locus: 1p36.31
Gene Diseases
The THAP3 LCK Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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