THAP1-SFRP1 Fusion FISH Probe
The THAP1-SFRP1 Fusion FISH Probe is used to confirm a fusion of the THAP1 and SFRP1 genes. The fusion of the THAP1 and SFRP1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| THAP1-SFRP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-RERE | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-REOR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-REGO | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-REGR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-REAQ | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-ORRE | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-OROR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-ORGO | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GORE | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GOOR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GOGO | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GOGR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GRRE | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GROR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GRGO | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GRGR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-AQRE | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-AQOR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-AQGO | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-AQGR | 20 (40 μL) | 200 μL |
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| THAP1-SFRP1-20-AQAQ | 20 (40 μL) | 200 μL |
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SFRP1 Gene Summary
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Gene Name: Secreted Frizzled Related Protein 1
Chromosome: CHR8: 41119475 -41166990
Locus: 8p11.21
THAP1 Gene Summary
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: THAP Domain Containing 1
Chromosome: CHR8: 42691816 -42698474
Locus: 8p11.21
Gene Diseases
The THAP1 SFRP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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