TGM2-ACVRL1 Fusion FISH Probe
The TGM2-ACVRL1 Fusion FISH Probe is used to confirm a fusion of the TGM2 and ACVRL1 genes. The fusion of the TGM2 and ACVRL1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TGM2-ACVRL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TGM2-ACVRL1-20-AQAQ | 20 (40 μL) | 200 μL |
|
ACVRL1 Gene Summary
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
Gene Name: Activin A Receptor Like Type 1
Chromosome: CHR12: 52301201 -52317145
Locus: 12q13.13
TGM2 Gene Summary
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Transglutaminase 2
Chromosome: CHR20: 36756863 -36793700
Locus: 20q11.23
Gene Diseases
The TGM2 ACVRL1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|