TGIF1-DDX19B Fusion FISH Probe
The TGIF1-DDX19B Fusion FISH Probe is used to confirm a fusion of the TGIF1 and DDX19B genes. The fusion of the TGIF1 and DDX19B genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TGIF1-DDX19B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-RERE | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-REOR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-REGO | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-REGR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-REAQ | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-ORRE | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-OROR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-ORGO | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GORE | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GOOR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GOGO | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GOGR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GRRE | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GROR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GRGO | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GRGR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-AQRE | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-AQOR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-AQGO | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-AQGR | 20 (40 μL) | 200 μL |
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| TGIF1-DDX19B-20-AQAQ | 20 (40 μL) | 200 μL |
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TGIF1 Gene Summary
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Gene Name: TGFB Induced Factor Homeobox 1
Chromosome: CHR18: 3412071 -3458406
Locus: 18p11.31
DDX19B Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: DEAD-box Helicase 19B
Chromosome: CHR16: 70333071 -70367731
Locus: 16q22.1
Gene Diseases
The TGIF1 DDX19B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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