TGFBR2-XPC Fusion FISH Probe
The TGFBR2-XPC Fusion FISH Probe is used to confirm a fusion of the TGFBR2 and XPC genes. The fusion of the TGFBR2 and XPC genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TGFBR2-XPC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-RERE | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-REOR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-REGO | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-REGR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-REAQ | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-ORRE | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-OROR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-ORGO | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-ORAQ | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GORE | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GOOR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GOGO | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GOGR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GOAQ | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GRRE | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GROR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GRGO | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GRGR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-GRAQ | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-AQRE | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-AQOR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-AQGO | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-AQGR | 20 (40 μL) | 200 μL |
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| TGFBR2-XPC-20-AQAQ | 20 (40 μL) | 200 μL |
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TGFBR2 Gene Summary
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Gene Name: Transforming Growth Factor Beta Receptor 2
Chromosome: CHR3: 30647993 -30735633
Locus: 3p24.1
XPC Gene Summary
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Gene Name: XPC Complex Subunit, DNA Damage Recognition And Repair Factor
Chromosome: CHR3: 14186647 -14220172
Locus: 3p25.1
Gene Diseases
The TGFBR2 XPC Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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