TGFBR2-NR2C2 Fusion FISH Probe
The TGFBR2-NR2C2 Fusion FISH Probe is used to confirm a fusion of the TGFBR2 and NR2C2 genes. The fusion of the TGFBR2 and NR2C2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TGFBR2-NR2C2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-RERE | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-REOR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-REGO | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-REGR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-REAQ | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-ORRE | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-OROR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-ORGO | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GORE | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GOOR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GOGO | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GOGR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GRRE | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GROR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GRGO | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GRGR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-AQRE | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-AQOR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-AQGO | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-AQGR | 20 (40 μL) | 200 μL |
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| TGFBR2-NR2C2-20-AQAQ | 20 (40 μL) | 200 μL |
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TGFBR2 Gene Summary
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Gene Name: Transforming Growth Factor Beta Receptor 2
Chromosome: CHR3: 30647993 -30735633
Locus: 3p24.1
NR2C2 Gene Summary
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Name: Nuclear Receptor Subfamily 2 Group C Member 2
Chromosome: CHR3: 14989235 -15090780
Locus: 3p25.1
Gene Diseases
The TGFBR2 NR2C2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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