TGFBI-TNNT1 Fusion FISH Probe
The TGFBI-TNNT1 Fusion FISH Probe is used to confirm a fusion of the TGFBI and TNNT1 genes. The fusion of the TGFBI and TNNT1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TGFBI-TNNT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-RERE | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-REOR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-REGO | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-REGR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-REAQ | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-ORRE | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-OROR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-ORGO | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GORE | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GOOR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GOGO | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GOGR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GRRE | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GROR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GRGO | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GRGR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-AQRE | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-AQOR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-AQGO | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-AQGR | 20 (40 μL) | 200 μL |
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| TGFBI-TNNT1-20-AQAQ | 20 (40 μL) | 200 μL |
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TGFBI Gene Summary
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
Gene Name: Transforming Growth Factor Beta Induced
Chromosome: CHR5: 135364583 -135399507
Locus: 5q31.1
TNNT1 Gene Summary
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Troponin T1, Slow Skeletal Type
Chromosome: CHR19: 55644160 -55660606
Locus: 19q13.42
Gene Diseases
The TGFBI TNNT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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