TFIP11-IL17RA Fusion FISH Probe
The TFIP11-IL17RA Fusion FISH Probe is used to confirm a fusion of the TFIP11 and IL17RA genes. The fusion of the TFIP11 and IL17RA genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TFIP11-IL17RA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-RERE | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-REOR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-REGO | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-REGR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-REAQ | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-ORRE | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-OROR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-ORGO | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-ORAQ | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GORE | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GOOR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GOGO | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GOGR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GOAQ | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GRRE | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GROR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GRGO | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GRGR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-GRAQ | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-AQRE | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-AQOR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-AQGO | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-AQGR | 20 (40 μL) | 200 μL |
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| TFIP11-IL17RA-20-AQAQ | 20 (40 μL) | 200 μL |
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IL17RA Gene Summary
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Gene Name: Interleukin 17 Receptor A
Chromosome: CHR22: 17565850 -17596584
Locus: 22q11.1
TFIP11 Gene Summary
This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Tuftelin Interacting Protein 11
Chromosome: CHR22: 26887893 -26908437
Locus: 22q12.1
Gene Diseases
The TFIP11 IL17RA Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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