TFAP2A-MAK Fusion FISH Probe
The TFAP2A-MAK Fusion FISH Probe is used to confirm a fusion of the TFAP2A and MAK genes. The fusion of the TFAP2A and MAK genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TFAP2A-MAK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-RERE | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-REOR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-REGO | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-REGR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-REAQ | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-ORRE | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-OROR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-ORGO | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-ORAQ | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GORE | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GOOR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GOGO | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GOGR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GOAQ | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GRRE | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GROR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GRGO | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GRGR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-GRAQ | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-AQRE | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-AQOR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-AQGO | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-AQGR | 20 (40 μL) | 200 μL |
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| TFAP2A-MAK-20-AQAQ | 20 (40 μL) | 200 μL |
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MAK Gene Summary
The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Male Germ Cell Associated Kinase
Chromosome: CHR6: 10762955 -10838788
Locus: 6p24.2
TFAP2A Gene Summary
The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
Gene Name: Transcription Factor AP-2 Alpha
Chromosome: CHR6: 10396915 -10419797
Locus: 6p24.3
Gene Diseases
The TFAP2A MAK Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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