TF-TYK2 Fusion FISH Probe
The TF-TYK2 Fusion FISH Probe is used to confirm a fusion of the TF and TYK2 genes. The fusion of the TF and TYK2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TF-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| TF-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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TF Gene Summary
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
Gene Name: Transferrin
Chromosome: CHR3: 133464976 -133497850
Locus: 3q22.1
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The TF TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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