TECR-PKN1 Fusion FISH Probe
The TECR-PKN1 Fusion FISH Probe is used to confirm a fusion of the TECR and PKN1 genes. The fusion of the TECR and PKN1 genes has been associated with Lung Squamous Cell Carcinoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TECR-PKN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-RERE | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-REOR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-REGO | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-REGR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-REAQ | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-ORRE | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-OROR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-ORGO | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GORE | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GOOR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GOGO | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GOGR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GRRE | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GROR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GRGO | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GRGR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-AQRE | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-AQOR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-AQGO | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-AQGR | 20 (40 μL) | 200 μL |
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| TECR-PKN1-20-AQAQ | 20 (40 μL) | 200 μL |
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PKN1 Gene Summary
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase N1
Chromosome: CHR19: 14544165 -14582679
Locus: 19p13.12
TECR Gene Summary
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]
Gene Name: Trans-2,3-enoyl-CoA Reductase
Chromosome: CHR19: 14640378 -14676792
Locus: 19p13.12
Gene Diseases
The TECR PKN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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