TEAD4-MAP3K12 Fusion FISH Probe
The TEAD4-MAP3K12 Fusion FISH Probe is used to confirm a fusion of the TEAD4 and MAP3K12 genes. The fusion of the TEAD4 and MAP3K12 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TEAD4-MAP3K12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-RERE | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-REOR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-REGO | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-REGR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-REAQ | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-ORRE | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-OROR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-ORGO | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-ORAQ | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GORE | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GOOR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GOGO | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GOGR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GOAQ | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GRRE | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GROR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GRGO | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GRGR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-GRAQ | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-AQRE | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-AQOR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-AQGO | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-AQGR | 20 (40 μL) | 200 μL |
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| TEAD4-MAP3K12-20-AQAQ | 20 (40 μL) | 200 μL |
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TEAD4 Gene Summary
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: TEA Domain Transcription Factor 4
Chromosome: CHR12: 3068477 -3149842
Locus: 12p13.33
MAP3K12 Gene Summary
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 12
Chromosome: CHR12: 53874275 -53893444
Locus: 12q13.13
Gene Diseases
The TEAD4 MAP3K12 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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