TDG-STAB2 Fusion FISH Probe
The TDG-STAB2 Fusion FISH Probe is used to confirm a fusion of the TDG and STAB2 genes. The fusion of the TDG and STAB2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TDG-STAB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-RERE | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-REOR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-REGO | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-REGR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-REAQ | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-ORRE | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-OROR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-ORGO | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GORE | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GOOR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GOGO | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GOGR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GRRE | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GROR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GRGO | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GRGR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-AQRE | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-AQOR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-AQGO | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-AQGR | 20 (40 μL) | 200 μL |
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| TDG-STAB2-20-AQAQ | 20 (40 μL) | 200 μL |
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TDG Gene Summary
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
Gene Name: Thymine DNA Glycosylase
Chromosome: CHR12: 104359592 -104382656
Locus: 12q23.3
STAB2 Gene Summary
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]
Gene Name: Stabilin 2
Chromosome: CHR12: 103981068 -104160502
Locus: 12q23.3
Gene Diseases
The TDG STAB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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