TCF4-MAML3 Fusion FISH Probe
The TCF4-MAML3 Fusion FISH Probe is used to confirm a fusion of the TCF4 and MAML3 genes. The fusion of the TCF4 and MAML3 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TCF4-MAML3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-RERE | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-REOR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-REGO | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-REGR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-REAQ | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-ORRE | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-OROR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-ORGO | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GORE | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GOOR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GOGO | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GOGR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GRRE | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GROR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GRGO | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GRGR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-AQRE | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-AQOR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-AQGO | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-AQGR | 20 (40 μL) | 200 μL |
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| TCF4-MAML3-20-AQAQ | 20 (40 μL) | 200 μL |
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TCF4 Gene Summary
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]
Gene Name: Transcription Factor 4
Chromosome: CHR18: 52889561 -53303188
Locus: 18q21.2
MAML3 Gene Summary
The Mastermind Like Transcriptional Coactivator 3 (MAML3) gene is located on chr4 :140637545-141075233 at 4q31.1.
Gene Name: Mastermind Like Transcriptional Coactivator 3
Chromosome: CHR4: 140637545 -141075233
Locus: 4q31.1
Gene Diseases
The TCF4 MAML3 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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