TCF3-APC2 Fusion FISH Probe
The TCF3-APC2 Fusion FISH Probe is used to confirm a fusion of the TCF3 and APC2 genes. The fusion of the TCF3 and APC2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TCF3-APC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-RERE | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-REOR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-REGO | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-REGR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-REAQ | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-ORRE | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-OROR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-ORGO | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GORE | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GOOR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GOGO | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GOGR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GRRE | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GROR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GRGO | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GRGR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-AQRE | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-AQOR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-AQGO | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-AQGR | 20 (40 μL) | 200 μL |
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| TCF3-APC2-20-AQAQ | 20 (40 μL) | 200 μL |
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TCF3 Gene Summary
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Gene Name: Transcription Factor 3
Chromosome: CHR19: 1609288 -1652328
Locus: 19p13.3
APC2 Gene Summary
This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Gene Name: APC2, WNT Signaling Pathway Regulator
Chromosome: CHR19: 1450147 -1473243
Locus: 19p13.3
Gene Diseases
The TCF3 APC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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