TCF20-MKL1 Fusion FISH Probe
The TCF20-MKL1 Fusion FISH Probe is used to confirm a fusion of the TCF20 and MKL1 genes. The fusion of the TCF20 and MKL1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TCF20-MKL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-RERE | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-REOR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-REGO | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-REGR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-REAQ | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-ORRE | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-OROR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-ORGO | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GORE | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GOOR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GOGO | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GOGR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GRRE | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GROR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GRGO | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GRGR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-AQRE | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-AQOR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-AQGO | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-AQGR | 20 (40 μL) | 200 μL |
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| TCF20-MKL1-20-AQAQ | 20 (40 μL) | 200 μL |
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TCF20 Gene Summary
This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: Transcription Factor 20
Chromosome: CHR22: 42556018 -42611445
Locus: 22q13.3
MKL1 Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291 -41032690
Locus: 22q13.1-q13.2
Gene Diseases
The TCF20 MKL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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